Table 1

ALX40-4C Inhibition of HIV-1 Replication

PBMCMT-2
StrainSI/NSI1 μM10 μM10 μM
NL4-3SI85>95>95
 1SI42  85>95
 2SI 7   3  90
 3SI73>95>90
 5SI 2   0>95
 6SI57>95>95
 7SI10   6   0
10SI 0  10>95
 4NSI 0   0
 8NSI 0   0
 9NSI 0   0
  • Human PBMCs or MT-2 cells were infected with 10 ng of the indicated primary virus strains or with NL4-3 in the presence of either 1 μM or 10 μM ALX40-4C. The amount of viral p24 (60–150 ng/ml for PBMC, 160–450 ng/ml for MT2 cells) released into the supernatant was measured 7 d later. Percentage inhibition is indicated. NSI strains did not grow on MT-2 cells.