Table 1

Circulating Leukocytes in WT and CD18−/− Mice

WTCD18−/−
No experimental inflammation
 Total leukocytes6.4 ± 0.9 (5.8)22.0 ± 3.2 (24.1)*
 Neutrophils1.0 ± 0.1 (0.8)10.6 ± 2.2 (8.7)*
Croton oil dermatitis
 Total leukocytes8.2 ± 1.1 (7.9)273 ± 232 (29.5)*
 Neutrophils1.9 ± 0.3 (1.5)235 ± 208 (18.6)*
E. coli pneumonia
 Total leukocytes1.7± 0.3 (1.6)54.2 ± 27.2 (27.1)*
 Neutrophils0.4 ± 0.1 (0.4)37.8 ± 19.5 (21.1)*
S. pneumoniae pneumonia
 Total leukocytes2.6 ± 0.4 (2.4)29.2 ± 2.9 (26.5)*
 Neutrophils0.7 ± 0.1 (0.7)21.1 ± 2.2 (18.5)*
4-h S. pneumoniae peritonitis
 Total leukocytes3.0 ± 0.6 (3.5)13.2 ± 1.7 (13.0)*
 Neutrophils1.2 ± 0.3 (1.3) 9.8 ± 1.7 (9.3)*
24-h S. pneumoniae peritonitis
 Total leukocytes3.7 ± 0.8 (3.9)19.4 ± 5.7 (15.7)*
 Neutrophils0.4 ± 0.04 (0.4)15.2 ± 5.2 (11.0)*
4-h thioglycollate peritonitis
 Total leukocytes5.6 ± 1.0 (5.2)27.4 ± 8.6 (27.2)*
 Neutrophils2.7 ± 0.6 (2.6)18.0 ± 5.5 (17.4)*
24-h thioglycollate peritonitis
 Total leukocytes4.6 ± 0.8 (4.0)38.2 ± 1.5 (39.2)*
 Neutrophils0.2 ± 0.1 (0.1)28.1 ± 1.4 (28.8)*
  • Blood was drawn from the inferior vena cava. Values represent mean ± SEM × 106 cells/ml. Median values are shown in parentheses.  

  • *  Significantly different from WT (P <0.05).