Table 2

Cosegregation of Thymocyte Deletion and Resistance to Insulitis and IDDM with H-2b and H-2k Haplotypes in 4.1-transgenic Mice*

H-2Deleting statusThymocyte profileAge at onsetInsulitis score ‡,∥ (n)
nCD4+CD8 (Vβ11+)CD4+CD8+CD4CD8CD4CD8+IDDM
%, x ± SD‖d  x ± SD
(NOD × B6) F1  × NODH-2g71531 ± 7a    44 ± 12  22 ± 7f3 ± 17/15k53 ± 172.4 ± 1.4 (8)p
(92 ± 2)a
H-2g7/b16+15 ± 3b    49 ± 12 33 ± 10g3 ± 10/16l0.4 ± 0.6 (16)q
(66 ± 5)b
(NOD × C58) F1  × NODH-2g7 935 ± 5c      43 ± 719 ± 4h3 ± 25/9m47 ± 163.4 ± 0.7 (4)r
(93 ± 1)c
H-2g7/k 635 ± 4d   45 ± 8  16 ± 6i4 ± 20/6n1.7 ± 1.2(6)s
(89 ± 9)d
H-2g7/k 9+17 ± 3e   45 ± 6  33 ± 6j4 ± 30/9o0.2 ± 0.2 (8)t
(58 ± 9)e
  • *  All mice were killed at IDDM onset or at 10 wk if nondiabetic. Flow cytometry was done as described in the legend to Fig. 1.  

  •  Nondiabetic mice only. Groups of mice include both male and female mice (∼ 50% each). No differences in the incidence of IDDM nor in the degree of insulitis were noted between female and male mice within groups. Insulitis (15–30 islets/mouse) was scored as described in Materials and Methods. a versus b,c versus e,d versus e,f versus g,h versus j,m versus j: P <0.0002; k versus l: P <0.0001; m versus n, m versus o, s versus t: P <0.002; p versus q: P <0.0006; r versus s: P <0.0007; r versus t: P <0.01 (compared by χ2

  • § ] and Mann-Whitney U test [ 

  • ]).