Table 1

Antigen-specific Cytokine Release by Splenocytes from Infected Mice*

IFN-γTNF-αIL-10IL-4IL-6
Control10186 ± 1059 ± 0207 ± 801455 ± 195
IL-12 p40−/−  129 ± 1135 ± 0272 ± 10 796 ± 470
  • *  Cytokine release was measured by sandwich ELISA of culture supernantant from cells incubated in the presence of antigens derived from M. tuberculosis.  

  •  Values are the mean and standard error (in pg/ml) of triplicate tests on pooled cells from four animals.