Table 1

Plasmon Resonance Analysis of Anti–4-1BB mAb Binding to 4-1BB–Ig Fusion Protein

AntibodyIsotypekakdkd/ka
M−1s−1s−1M
1D8IgG2A 2.9 × 105 1.2 × 10−44.14 × 10−10
22B6IgG2A 5.7 × 105 1.5 × 10−42.63 × 10−10
3H3IgG2A 3.7 × 105 1.9 × 10−45.14 × 10−10
15B9IgG2A 4.3 × 105 1.1 × 10−42.56 × 10−10
3E1IgG2A 5.7 × 105 1.3 × 10−52.28 × 10−11
5C12IgG2A 5.6 × 105 1.5 × 10−42.68 × 10−10
21E5IgG2A 5.3 × 105 1.1 × 10−41.99 × 10−10
3B8IgM 2.8 × 10−5
4-1BB Ligand1.83 × 1052.13 × 10−41.16 × 10−9