Table 1

CDR3 Sequences of Vα24+Vβ11+ Clones

T cellVα24JαQ*TCR-β
Vβ11CDR3
DN1.10B3++CASREGAMGTGELFFGEG Jβ2.2
DN2.B9++CASSATRALTGSDTQYFGPG Jβ2.3
DN2.C6++CASSFLDRDYSYNEQFFGPG Jβ2.1
DN2.C7++CASSENRQGAGYEQYFGPG Jβ2.7
DN2.C9++CAS2 Vβ11 sequences‡
DN2.D5++CASSERTTNTGELFFGEG Jβ2.2
DN2.D6++CASSVRPGGNEQFFGPG Jβ2.1
DN2.D7++CASSDGEQANTEAFFGQG Jβ1.1
DN3.2++CASSATIRDRASGYTFGSG Jβ1.2
SP3.1 (CD4)+CASSDTRVGGELFFGEG Jβ2.2
SP3.4 (CD4)+CASSLGESNQPQHFGDG Jβ1.5
SP3.7 (CD4)+CASSVPGPAYEQYFGPG Jβ2.7
SP3.11 (CD4)+CASSDTRVGGELFFGEG Jβ2.2
SP3.15 (CD4)+CASGTQGNTEAFFGQG Jβ1.1
SP3.19 (CD4)+CASEYGGPSYGYTFGSG Jβ1.2
  • *  Sequencing confirmed that all JαQ+ TCRs expressed the invariant Vα24 TCR-α chain.  

  •  Sequencing indicated that two Vβ11 transcripts were expressed, presumably reflecting two clones.