Table 1

Sequences of Synthetic ODN

ODNSequence*MotifBackbone
          ↓ ↓         ↓ ↓
1826 TCCATGACGTTCCTGACGTTCpGS ODN
1745TCCAATGAGCTTCCTGAGTCTnon-CpGS ODN
     ↓ ↓    ↓ ↓
1760ATAATCGACGTTCAAGCAAGCpGS ODN
1908ATAATAGAGCTTCAAGCAAGnon-CpGS ODN
        ↓ ↓
1585 GGGGTCAACGTTGAGGGGGGCpGS-O ODN
1972GGGGTCTGTGCTTTTGGGGGGnon-CpGS-O ODN
  • Nucleotides that have their 3′ linkage phosphorothioate modified to increase resistance to nuclease degradation are in bold print.  

  • *  The CpG motifs or corresponding non-CpG motifs are underlined.