Table 1

EBV Lytic Antigen-specific CTL Reactivities

EBV antigenEpitope location, sequenceHLA restrictionCTL donor*
BZLF1190-197, RAKFKQLLB8IM53, IM59, IM63
BRLF1NDA2.05IM63
NDNDIM55
BMLF1265-273, KDTWLDARMNDKG
280-288, GLCTLVAMLA2.01IM61, IM69
397-405, DEVEFLGHYB18IM53
NDA24IM55
BMRF186-100, FRNLAYGRTCVLGKE‡C3IM55
268-276, YRSGIIAVVC6IM63
BALF2NDB39CG
NDC6IM55
  • *  Assays were carried out on ex vivo primary effectors from IM53, IM55, IM59, IM61, IM63, and IM69, on in vitro–expanded polyclonal primary CTLs from IM53, IM59, and IM63, on in vitro–expanded primary CTL clones from IM53, IM55, IM59, IM63, and IM69, on in vitro–expanded polyclonal memory CTLs from post-IM53, post-IM59, and post-IM63, and on in vitro–expanded memory CTL clones from post-IM63, KG, and CG.  

  •  Miminal epitope not yet defined.