Table 1

T Cell Proliferative Response of DR Tg+ and Tg Mice to hCII

Strain[3H]Thymidine incorporation (Δ DPM)*
Human α1(II) chain
50 μg25 μg
B10.M DR1 Tg+/+81,463 ± 3,86658,030 ± 319
B10.M Tg/14,906 ± 1,99312,592 ± 2,576
  • *  T cell proliferation assays were performed 10 d after immunization with hCII as described in Materials and Methods. Data are expressed as Δ decays per minute (DPM), (experimental − control) ± SEM. Control stimulations: B10.M DR1 Tg+/+, 1,796 DPM; B10.M Tg/, 3,850 DPM.