Table 1

Influence of LCMV Isolate, Virus Dose, and IFN Responder Status on Circulating Reticulocytes 3 d after LCMV Infection

Mouse strainH-2IFN peak titer (LCMV)‡Percent reduction of reticulocyte numbers in blood
Low dose (2 × 102 PFU)*High dose (2 × 106 PFU)*
ArmstrongWEDocileArmstrongWEDocile
C57BL/6bh50 ± 460 ± 752 ± 896 ± 196 ± 1ND
DBA/2dl20 ± 926 ± 920 ± 1195 ± 295 ± 1ND
BALB/cdl17 ± 221 ± 816 ± 284 ± 389 ± 3ND
CBA/Jkh64 ± 174 ± 160 ± 196 ± 196 ± 1ND
C3H/HeJkh61 ± 769 ± 752 ± 4NDNDND
  • *  Mice were infected i.v. with the indicated doses of LCMV. Reticulocyte numbers were determined cytofluorometrically in blood collected from the retrobulbar plexus on day 3 after infection; values are presented as percent below baseline values, as determined in uninfected control mice. Indicated are means ± SD of three mice.  

  •  Relative serum IFN-α/β peak titers as assessed after infection with different LCMV isolates (39, 40).