Table 1. Characterization of cardiac function in WT, in TCR-α−/−, and in TCR-α−/− mice after AT of naive, Th1, or IFN-γ−/− Th cells 4 wk after sham or TAC
ParametersWT shamWT TACTCR-α−/− ShamTCR-α−/− TACTCR-α−/− TAC AT NaiveTCR-α−/− TAC AT Th1TCR-α−/− TAC AT IFN-γ−/−Th
Total mouse weight (g)/tibia length (mm)1.45 ± 0.021.43 ± 0.021.45 ± 0.031.49 ± 0.041.46 ± 0.041.51 ± 0.011.48 ± 0.03
Lung weight (mg)/tibia length (cm)91.77 ± 2123 ± 9a87.33 ± 388.11 ± 092.39 ± 292.32 ± 192.41 ± 2
Fractional shortening (%)39.54 ± 4.03623.80 ± 2.29a30.92 ± 3.2238.46 ± 4.1031.25 ± 3.3632.24 ± 3.8730.88 ± 3.90
Anterior wall thickness (mm)0.87 ± 0.031.08 ± 0.08a0.75 ± 0.020.87 ± 0.030.83 ± 0.141.10 ± 0.11a,b0.90 ± 0.10
Posterior wall thickness (mm)0.94 ± 0.051.3 ± 0.07a0.73 ± 0.031.01 ± 0.120.83 ± 0.141.02 ± 0.07c0.87 ± 0.08
End diastolic diameter (mm)3.49 ± 0.083.99 ± 0.15a4.01 ± 0.123.9 ± 0.224.16 ± 0.163.97 ± 0.184.08 ± 0.12
End systolic diameter (mm)2.11 ± 0.163.04 ± 0.17d2.77 ± 0.202.60 ± 0.282.86 ± 0.232.69 ± 0.242.82 ± 0.17
dp/dt min (mm Hg/s)−8.28 ± 0.86−5.61 ± 0.68a−7.89 ± 0.39−8.00 ± 1.06−8.76 ± 1.06−6.67± 0.70−7.61 ± 1.12

Values are means ± SEM.

  • a P < 0.05, 4 wk of TAC versus sham.

  • b P < 0.05, 4 wk TAC AT TCR-α−/− versus TAC TCR-α−/−.

  • c P < 0.01, 4 wk TAC AT TCR-α−/− versus TAC TCR-α−/−.

  • d P < 0.01, 4 wk of TAC versus sham.