Table 2. EFS association with conserved IKAROS-repressed and IKAROS-activated gene expression in patient cohorts separated by IKZF1 deletion/mutation status
GeneUS cohortDCOG/COALL cohort
Total cohort (n = 289)IKZF1 wild-type (n = 144)IKZF1 mutated/deleted (n = 103)Total cohort (n = 573)no IKZF1 deletion (n = 371)IKZF1 deletion (n = 139)
Hazard ratio95% CIP-valueHazard ratio95% CIP-valueHazard ratio95% CIP-valueHazard ratio95% CIP-valueHazard ratio95% CIP-valueHazard ratio95% CIP-value
Ikaros-activated
CTNND11.981.26–3.151.2 × 10−31.670.80–3.441.7 × 10−11.340.75–2.423.2 × 10−12.921.93–3.962.9 × 10−82.851.60–4.522.0 × 10−42.131.19–3.771.1 × 10−2
EMP12.481.54–3.855.0 × 10−52.421.19–5.231.7 × 10−21.961.11–3.612.2 × 10−22.061.41–2.891.2 × 10−42.501.42–4.011.0 × 10−31.210.68–2.145.1 × 10−1
FXYD62.631.86–5.101.0 × 10−61.500.63–3.793.4 × 10−12.261.28–4.166.1 × 10−31.471.03–2.103.5 × 10−21.330.79–2.242.8 × 10−11.500.84–2.651.7 × 10−1
IFITM32.541.60–4.012.0 × 10−51.390.68–2.903.7 × 10−12.061.15–3.721.6 × 10−21.791.24–2.541.7 × 10−31.390.83–2.332.2 × 10−11.891.06–3.343.1 × 10−2
CTNNBIP11.320.84–2.082.9 × 10−11.320.64–2.754.5 × 1011.090.61–1.957.8 × 10−11.410.98–2.016.2 × 10−21.050.62–1.768.6 × 1011.110.62–1.967.3 × 10−1
S100A161.701.08–2.703.4 × 10−21.020.49–2.109.7 × 10−10.870.48–1.566.3 × 10−11.260.88–1.812.0 × 10−12.061.20–3.398.0 × 10−30.920.52–1.647.8 × 10−1
ROBO41.370.87–2.161.5 × 10−11.170.57–2.436.7 × 10−11.170.65–2.105.9 × 10−11.691.17–2.404.7 × 10−31.160.69–1.965.7 × 10−12.071.16–3.641.4 × 10−2
AGAP31.931.24–3.111.7 × 10−31.910.92–3.958.5 × 10−21.480.84–2.721.8 × 10−11.641.14–2.337.4 × 10−31.360.81–2.282.5 × 10−11.540.87–2.741.4 × 10−1
ITPRIPL21.560.99–2.474.6 × 10−21.870.90–3.889.4 × 10−20.900.50–1.627.3 × 10−12.171.49–3.053.5 × 10−51.931.13–3.191.6 × 10−22.011.13–3.581.8 × 10−2
Ikaros-repressed
CSF2RB1.270.81–2.013.0 × 10−11.270.61–2.635.2 × 10−10.600.34–1.089.1 × 10−22.201.50–3.082.8 × 10−51.590.94–2.658.6 × 10−21.540.87–2.741.4 × 10−1
C1GALT10.980.62–1.549.0× 10−10.810.39–1.685.7 × 10−10.900.50–1.617.2 × 10−11.661.15–2.356.7 × 10−31.560.92–2.619.8 × 10−21.470.83–2.601.9 × 10−1
ASL0.900.57–1.426.4 × 10−11.030.50-2.139.4 × 10−11.110.57–1.829.6 × 10−11.280.89–1.821.8 × 10−11.670.99–2.805.6 × 10−10.850.48–1.505.7 × 10−1
ORAI21.691.08–2.682.4 × 10−22.111.01-4.334.8 × 0.890.50–1.596.9 × 10−11.471.03–2.103.5 × 10−21.080.64–1.817.8 × 10−11.560.88–2.761.3 × 10−1

Log rank P-values are shown. Genes where EFS is not significantly different (P > 0.05) are italicized.