Table 1. Biomarkers in peripheral tissues
mtHtt staining4-HNE staining
Muscle
WT TAT80.8 ± 2.045.1 ± 2.8
WT P11094.8 ± 0.5
R6/2 TAT143.3 ± 0.4a91.8 ± 2.5b
R6/2 P11057.1 ± 0.6c
Skin
WT TAT96.4 ± 4.295.3 ± 2.8
WT P11089.4 ± 3.3
R6/2 TAT141 ± 5.0d148.6 ± 7.0e
R6/2 P11085.7 ± 3.5f

Quantification of images of mtHtt and 4-HNE staining in muscle and skin. Images of the respective staining were obtained from three mice/group, and 16 areas of each section were analyzed. 58 areas of each section were analyzed for mtHtt staining in muscle. Data are presented as mean ± SEM.

  • a P = 0.038 (WT TAT vs. R6/2 TAT)

  • b P = 0.0026 (WT TAT vs. R6/2 TAT)

  • c P = 0.027 (R6/2 TAT vs. R6/2 P110)

  • d P = 0.019 (WT TAT vs. R6/2 TAT)

  • e P = 0.018 (WT TAT vs. R6/2 TAT)

  • f P = 0.015 (R6/2 TAT vs. R6/2 P110)