Table 1.

Common genes responsive to TGF-β in MeT-5A and Y-MESO-27 cells

MeT-5A and Y-MESO-27 common genes up (>1.5fold)
CSF1Rcolony-stimulating factor 1 receptor
SNAI1snail homologue 1
LOX*lysyl oxidase
RASGRP1RAS guanyl-releasing protein 1
MMP2*matrix metallopeptidase 2
ITGA11*integrin, alpha 11
SERPINE1plasminogen activator inhibitor type 1
BMP6bone morphogenetic protein 6
GDF6growth differentiation factor 6
COL1A1*Prepro-alpha1(I) collagen
EDN1endothelin 1
COL1A2*collagen, type I, alpha 2
MFAP4microfibrillar-associated protein 4
SERPINE2plasminogen activator inhibitor type 1, member 2
COL20A1*collagen, type XX, alpha 1
COL5A1*collagen, type V, alpha 1
ITGB3*integrin, beta 3
LTBP2latent transforming growth factor beta binding protein 2
SMAD7SMAD family member 7
COL7A1*collagen, type VII, alpha 1
SKILSKI-like oncogene
COL4A1*collagen, type IV, alpha 1
TGFB1transforming growth factor, beta 1
ITGAV*integrin, alpha V (vitronectin receptor)
IGFBP3insulin-like growth factor binding protein 3
COL4A4*collagen, type IV, alpha 4
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)
GADD45Bgrowth arrest and DNA-damage-inducible, beta
ADAM12ADAM metallopeptidase domain 12
BMPR2bone morphogenetic protein receptor, type II
ITGA1*integrin, alpha 1
COL16A1*collagen, type XVI, alpha 1
TGFB2transforming growth factor, beta 2
EGR2early growth response 2
CTGF*connective tissue growth factor
ID3inhibitor of DNA binding 3
MeT-5A and Y-MESO-27 common genes down (<0.67-fold)
IL6Rinterleukin 6 receptor
VCAM1vascular cell adhesion molecule 1
CASP1caspase 1, apoptosis-related cysteine peptidase
IL12Ainterleukin 12, alpha
IL1Ainterleukin 1, alpha
IL7interleukin 7
FASTNF receptor superfamily, member 6
MMP26*matrix metallopeptidase 26
FGF23fibroblast growth factor 23
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha
NEDD4Lneural precursor cell expressed, developmentally down regulated 4-like
COL24A1*collagen, type XXIV, alpha 1
TGFAtransforming growth factor, alpha
CAMK2Dcalcium/calmodulin-dependent protein kinase II delta
TLR3toll-like receptor 3
BCL2B-cell CLL/lymphoma 2
  • MeT-5A and Y-MESO-27 cells were treated with TGF-β for 24 h. Total RNA was extracted and subjected to microarray analysis. The genes encoding ECM-related protein are indicated by an asterisk.