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ON THE COVER
Image (provided by Pietro M. Motta and Tomonori Naguro / Photo Researchers, Inc) shows a colored high resolution scanning electron micrograph of two lysosomes in a pancreatic acinar cell. When the lysosomal membrane protein TRP-ML1 is mutated, the lysosome internalizes endosomal lipid cargo but fails to digest it, causing a lipid pile-up (top). Related story by Miedel et al.
See page 1477
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