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Cover picture: The image shows uptake of rod cell fragments (green) by primary retinal epithelial cells (with red nuclei) from wild-type mice in a model of age-related blindness. In mice lacking αvβ5 integrin expression, rod cell fragments are phagocytosed by retinal epithelial cells but cannot be digested, causing a toxic buildup of rod cell debris that eventually leads to blindness. See related article by Nandrot et al.,pp. 1539-1545
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