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COVER PICTURE:
11 d after intravenous transplantation of marrow stem cells into nonirradiated
recipients, early intrathymic progenitors (red) remain in the peri-medullary
cortex. This corresponds to the region where they first enter the organ after
leaving the blood, indicating that the early steps of T lineage commitment occur
within a relatively confined tissue space. Cortical and medullary regions can
be distinguished by the morphology of cytokeratin-expressing stromal cells (green),
and on the density of lymphoid nuclei (blue). Donor cells found in the medulla
(red) are DCs that arise coherently with T cells after each wave of new progenitor
recruitment.
See related article by Porritt et al., pp.
957-962.
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