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COVER PICTURE: Phosphatidylinositol-3-phosphate (PI3P) colocalizes (yellow) with maturing phagosomes (red), revealed by live microscopy using a PI3P-specific probe, p40PX-EGFP (green). The article by Vergne et al. in this issue shows that PI3P generation on phagosomes is calmodulin dependent, and that M. tuberculosis trafficking toxin, LAM, inhibits the newly described Ca 2/CaM/phosphatidylinositol 3-kinase hVPS34 signaling cascade. LAM-dependent inhibition of this pathway prevents conversion of M. tuberculosis phagosome into phagolysosome. Also, see supplemental movie with the article. Image was prepared for cover art courtesy of Jennifer Chua and Isabelle Vergne. See related article by Vergne et al., pp. 653-659.
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