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COVER PICTURE:
After a ripple of 
cell death that occurs physiologically around 2 wk of age in mice of all strains, antigens derived from dead cells (black cells) are taken up by dendritic cells (DCs) (blue cells) in the pancreatic islets (top left), inducing their migration to the pancreatic lymph node (PLN) (bottom right) and their maturation en route.
In the PLN, the DCs present cell-derived antigens to naive cell-reactive T cells (white cells) in circulation and activate them.
Upon recognition of MHC molecule- cell peptide complexes, the naive T cells become activated (red cells), acquiring the ability to migrate through the tissues.
In the islets, the activated T cells reencounter cognate antigen, become reactivated, and are retained, thereby initiating insulitis.
See related article by Turley et al., pp.
1527-1537.
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