About the Cover
The Journal of Experimental Medicine
193
12
In eukaryotes, DNA associates with histones to form nucleosomes. Both the extensive histone�DNA contacts in individual nucleosomes and the folding of the chain of nucleosomes into higher order chromatin fibers limit the accessibility of DNA to transcription factors. The drawing shows a nucleosomal chain with accessible and inaccessible binding sites (in red) for the transcription factor nuclear factor (NF)-kappaB. Several inflammatory stimuli trigger the nuclear relocalization of NF-kappaB. Regulation of NF-kappaB site accessibility through acetylation of nucleosomal histones contributes to control the specificity of NF-kappaB�dependent transcription. The ability of individual stimuli to make NF-kappaB sites accessible before loss of the transcription factor from the nucleus may dictate which NF-kappaB�dependent genes are transcribed during an acute NF-kappaB response. See related article in this issue by Saccani et al., pp.
1351-1359,
respectively. Cover design by Bob Crimi.
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