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Figure S7.Blocking the Tim-3 signaling pathway by the addition of soluble Tim-3 enhances IFN-γ production of T cells. PBMCs from HIV-1–uninfected subjects were stained with CFSE, and the effect of sTim-3 on cytokine production and proliferation of PBMCs (CFSElo IFN-γ+) was determined in these individuals over a 6-d stimulation assay using a combination of anti-CD3 and anti-CD28 purified mAbs. Shown is a graphical representation of the MFI of IFN-γ production in the proliferated (CFSElo) subset of CD8+ T cells with the addition of either sTim-3 or control (n = 6).