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Figure S4.Functionality of Tim-3–expressing CD8+ T cells in a representative HIV-1–infected and –uninfected individual. PBMCs from five HIV-1–infected and five HIV-1–uninfected subjects were stimulated with pooled HIV-1–Gag peptides or SEB for 6 h. Cytokine production and Tim-3 expression were assessed by intracellular cytokine staining using monoclonal antibodies to IFN-γ, TNF-α, CD3, CD8, and Tim-3.