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Figure S2.CNI-1493 inhibits soluble Aβ formation in transgenic APP TgCRND8 mice. Brain cytosol lysates (10 µg/lane) were isolated from APPTgCRND8 mice treated with vehicle (lanes 1–5) or CNI-1493 (lanes 6–9) and prepared for immunoblot using anti-Aβ (top) or anti-GAPDH (bottom) antibodies. Note the dramatic reduction in soluble Aβ oligomers in the brains of CNI-1493–treated animals.