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Figure S3. The cAMP-antagonist Rp-cAMPS abrogates nTreg-mediated suppression. Conventional CD4+ T cells were activated separately or in co-culture with nTregs at variable ratios with anti-CD3 mAb and A20 as accessory cells. If indicated, either the specific cAMP-antagonist Rp-cAMPS (4 mM) or its solvent was added. Proliferation was assessed after four days as cpm. One representative assay performed in triplicates +/- SD is shown.