EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

Alessandro Malara; Cristian Gruppi; Vittorio Abbonante; Daniele Cattaneo; Luigi De Marco; Margherita Massa; Alessandra Iurlo; Umberto Gianelli; Carlo L. Balduini; Maria E. Tira; Andrès F. Muro; Anil K. Chauhan; Vittorio Rosti; Giovanni Barosi; Alessandra Balduini

doi:10.1084/jem.20181074

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EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

Alessandro Malara, Cristian Gruppi, View ORCID ProfileVittorio Abbonante, Daniele Cattaneo, View ORCID ProfileLuigi De Marco, Margherita Massa, Alessandra Iurlo, View ORCID ProfileUmberto Gianelli, Carlo L. Balduini, Maria E. Tira, View ORCID ProfileAndrès F. Muro, Anil K. Chauhan, Vittorio Rosti, Giovanni Barosi, View ORCID ProfileAlessandra Balduini Correspondence email

Alessandro Malara

Department of Molecular Medicine, University of Pavia, Pavia, ItalyLaboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy

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Cristian Gruppi

Department of Molecular Medicine, University of Pavia, Pavia, Italy

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Vittorio Abbonante

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Daniele Cattaneo

Hematology Division, Istituto di Ricovero e Cura a Carattere Scientific Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy

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Luigi De Marco

Department of Translational Research, National Cancer Center (Istituto di Ricovero e Cura a Carattere Scientific Centro di Riferimento Oncologico), Aviano, ItalyDepartment of Molecular and Experimental Research, The Scripps Research Institute, La Jolla, CA

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Margherita Massa

Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy

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Alessandra Iurlo

Hematology Division, Istituto di Ricovero e Cura a Carattere Scientific Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy

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Umberto Gianelli

Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

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Carlo L. Balduini

Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientific San Matteo Foundation, Pavia, Italy

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Maria E. Tira

Department of Biology and Biotechnology “Lazzaro Spallanzani,” University of Pavia, Pavia, Italy

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Andrès F. Muro

The International Center for Genetic Engineering and Biotechnology, Trieste, Italy

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Anil K. Chauhan

Department of Internal Medicine, University of Iowa, Iowa City, IA

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Vittorio Rosti

Center for the Study of Myelofibrosis, Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics, Istituto di Ricovero e Cura a Carattere Scientific Policlinico S. Matteo Foundation, Pavia, Italy

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Giovanni Barosi

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Alessandra Balduini

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ORCID record for Alessandra Balduini
For correspondence: alessandra.balduini@tufts.edu

DOI: 10.1084/jem.20181074 | Published February 7, 2019

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EDA fibronectin–TLR4 axis sustains megakaryocyte expansion and inflammation in bone marrow fibrosis

Alessandro Malara, Cristian Gruppi, Vittorio Abbonante, Daniele Cattaneo, Luigi De Marco, Margherita Massa, Alessandra Iurlo, Umberto Gianelli, Carlo L. Balduini, Maria E. Tira, Andrès F. Muro, Anil K. Chauhan, Vittorio Rosti, Giovanni Barosi, Alessandra Balduini

Journal of Experimental Medicine Feb 2019, jem.20181074; DOI: 10.1084/jem.20181074