ON THE COVER
Rodriguez-Laguna et al. show that somatic mutations in PIK3CA can cause generalized lymphatic anomaly in humans. The cover shows the hyperplastic lymphatic network in a mouse model that expresses one of the mutations identified in humans (Pik3ca H1074R), specifically within their lymphatic endothelial cells. The image was taken from the original manuscript and modified by the JEM editorial office. See page 407.