Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

Amanda J. Lee; Branson Chen; Marianne V. Chew; Nicole G. Barra; Mira M. Shenouda; Tina Nham; Nico van Rooijen; Manel Jordana; Karen L. Mossman; Robert D. Schreiber; Matthias Mack; Ali A. Ashkar

doi:10.1084/jem.20160880

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

Amanda J. Lee, View ORCID ProfileBranson Chen, Marianne V. Chew, View ORCID ProfileNicole G. Barra, Mira M. Shenouda, Tina Nham, Nico van Rooijen, View ORCID ProfileManel Jordana, Karen L. Mossman, View ORCID ProfileRobert D. Schreiber, Matthias Mack, View ORCID ProfileAli A. Ashkar

Amanda J. Lee

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Branson Chen

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Branson Chen

Marianne V. Chew

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nicole G. Barra

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nicole G. Barra

Mira M. Shenouda

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tina Nham

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nico van Rooijen

Department of Molecular Cell Biology, Vrije University Medical Center, 1081 HV Amsterdam, Netherlands

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Manel Jordana

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Manel Jordana

Karen L. Mossman

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert D. Schreiber

Washington University School of Medicine, St. Louis, MO 63110

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Robert D. Schreiber

Matthias Mack

RCI Regensburg Center for Interventional Immunology, University of Regensburg, 93053 Regensburg, Germany

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ali A. Ashkar

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ali A. Ashkar

DOI: 10.1084/jem.20160880 | Published March 6, 2017

Article
Figures & Data
Info
Metrics
Preview PDF

You are using an old browser, click here to download PDF

PDF Container

Previous articleNext article

Download PDF

Citation Tools

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection

Amanda J. Lee, Branson Chen, Marianne V. Chew, Nicole G. Barra, Mira M. Shenouda, Tina Nham, Nico van Rooijen, Manel Jordana, Karen L. Mossman, Robert D. Schreiber, Matthias Mack, Ali A. Ashkar

Journal of Experimental Medicine Apr 2017, 214 (4) 1153-1167; DOI: 10.1084/jem.20160880