Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Öhlund; Abram Handly-Santana; Giulia Biffi; Ela Elyada; Ana S. Almeida; Mariano Ponz-Sarvise; Vincenzo Corbo; Tobiloba E. Oni; Stephen A. Hearn; Eun Jung Lee; Iok In Christine Chio; Chang-Il Hwang; Hervé Tiriac; Lindsey A. Baker; Dannielle D. Engle; Christine Feig; Anne Kultti; Mikala Egeblad; Douglas T. Fearon; James M. Crawford; Hans Clevers; Youngkyu Park; David A. Tuveson

doi:10.1084/jem.20162024

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

View ORCID ProfileDaniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, View ORCID ProfileAna S. Almeida, Mariano Ponz-Sarvise, View ORCID ProfileVincenzo Corbo, View ORCID ProfileTobiloba E. Oni, View ORCID ProfileStephen A. Hearn, Eun Jung Lee, Iok In Christine Chio, View ORCID ProfileChang-Il Hwang, Hervé Tiriac, View ORCID ProfileLindsey A. Baker, View ORCID ProfileDannielle D. Engle, Christine Feig, Anne Kultti, View ORCID ProfileMikala Egeblad, View ORCID ProfileDouglas T. Fearon, James M. Crawford, Hans Clevers, Youngkyu Park, View ORCID ProfileDavid A. Tuveson

Daniel Öhlund

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724Department of Surgical and Perioperative Sciences, Surgery, Umeå University, 901 85 Umeå, Sweden

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Abram Handly-Santana

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Giulia Biffi

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Ela Elyada

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Ana S. Almeida

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724APC Microbiome Institute and School of Microbiology, University College Cork, Cork, Ireland

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ORCID record for Ana S. Almeida

Mariano Ponz-Sarvise

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724Department of Oncology, Clinica Universidad de Navarra, CIMA, IDISNA, Pamplona 31008, Spain

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Vincenzo Corbo

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724ARC-Net centre for applied research on cancer, University and Hospital Trust of Verona, 37134 Verona, ItalyDepartment of Diagnostic and Public Health, University and Hospital Trust of Verona, 37134 Verona, Italy

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Tobiloba E. Oni

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY 11794

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Stephen A. Hearn

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

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Eun Jung Lee

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Iok In Christine Chio

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Chang-Il Hwang

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Hervé Tiriac

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Lindsey A. Baker

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Dannielle D. Engle

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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Christine Feig

University of Cambridge, Cancer Research UK, Cambridge Institute, Cambridge, UK

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Anne Kultti

University of Cambridge, Cancer Research UK, Cambridge Institute, Cambridge, UK

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Mikala Egeblad

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

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Douglas T. Fearon

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724

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James M. Crawford

Hofstra Northwell School of Medicine, Hempstead, NY 11550

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Hans Clevers

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Centre Utrecht and CancerGenomics.nl, 3584 CT Utrecht, Netherlands

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Youngkyu Park

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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David A. Tuveson

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724

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ORCID record for David A. Tuveson

DOI: 10.1084/jem.20162024 | Published February 23, 2017

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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Öhlund, Abram Handly-Santana, Giulia Biffi, Ela Elyada, Ana S. Almeida, Mariano Ponz-Sarvise, Vincenzo Corbo, Tobiloba E. Oni, Stephen A. Hearn, Eun Jung Lee, Iok In Christine Chio, Chang-Il Hwang, Hervé Tiriac, Lindsey A. Baker, Dannielle D. Engle, Christine Feig, Anne Kultti, Mikala Egeblad, Douglas T. Fearon, James M. Crawford, Hans Clevers, Youngkyu Park, David A. Tuveson

Journal of Experimental Medicine Mar 2017, 214 (3) 579-596; DOI: 10.1084/jem.20162024