ON THE COVER
Öhlund et al. establish a three-dimensional co-culture platform of pancreatic cancer organoids (purple) and pancreatic stellate cells (light blue) to model the tumor–stroma interactions in pancreatic ductal adenocarcinoma (PDA). Using this platform, the authors identify subpopulations of cancer-associated fibroblasts that highlight the heterogeneity of PDA stroma in vivo. Cover image provided by the authors and modified by the JEM office.
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