SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang; Yingjun Zhao; Lu-lin Jiang; Xiaoguang Li; Yan Liu; Yu Sun; Juan C. Piña-Crespo; Bing Zhu; Eliezer Masliah; Thomas E. Willnow; Elena B. Pasquale; Huaxi Xu

doi:10.1084/jem.20171413

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang, Yingjun Zhao, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, View ORCID ProfileJuan C. Piña-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, View ORCID ProfileElena B. Pasquale, View ORCID ProfileHuaxi Xu Correspondence email

Timothy Y. Huang

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Yingjun Zhao

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Lu-lin Jiang

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Xiaoguang Li

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Yan Liu

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CAFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, China

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Yu Sun

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Juan C. Piña-Crespo

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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ORCID record for Juan C. Piña-Crespo

Bing Zhu

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

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Eliezer Masliah

Department of Pathology, University of California, San Diego, La Jolla, CADepartment of Neuroscience, University of California, San Diego, La Jolla, CA

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Thomas E. Willnow

Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany

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Elena B. Pasquale

Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CADepartment of Pathology, University of California, San Diego, La Jolla, CA

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ORCID record for Elena B. Pasquale

Huaxi Xu

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For correspondence: xuh@sbpdiscovery.org

DOI: 10.1084/jem.20171413 | Published November 7, 2017

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SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang, Yingjun Zhao, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan C. Piña-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu

Journal of Experimental Medicine Dec 2017, 214 (12) 3669-3685; DOI: 10.1084/jem.20171413