January 2016 | Volume 213, No. 1
- Ubiquitin in the activation and attenuation of innate antiviral immunity
Heaton and colleagues discuss regulation of viral-sensing pathways by protein ubiquitination and how viruses subvert the ubiquitin system.
- Immunometabolism governs dendritic cell and macrophage function
In this review, O’Neill and Pearce discuss recent intriguing findings on metabolic changes regulating the function of macrophages and dendritic cells.
Brief Definitive Report
- Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles
Hatlen et al. provide an integrative analysis of the mutational landscape of mouse and human AML and identify functionally relevant cooperation between AML1-ETO and PTPN11 D61Y. Based on these findings, they generate a novel mouse model of t(8;21)+ AML.
- Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12
Everts et al. use Batf3−/− mice to examine the role of Batf3-dependent CD8α+ and CD103+ DCs in Th2 immunity in response to helminth infection. Loss of Batf3-dependent DCs resulted in rapid control of normally chronic infection with Heligmosomoides polygyrus, whereas liver fibrosis was exacerbated with Schistosoma mansoni infection. Mechanistically, steady-state IL-12 production by migratory CD103+ DCs was found to antagonize Th2 responses.
- Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses
Ruane et al. demonstrate a role for the microbiota in modulating protective immunity to intranasal vaccination via the ability of lung dendritic cells to induce B cell IgA class switching.
- XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses
Alexandre et al. demonstrate the XCR1+ DCs are instrumental in memory CD8+ T cell responses to Listeria, VSV or vaccinia virus infection, but not CMV. Depending on the infection, robust memory CTL responses require cytokine- and chemokine-dependent cross-talk between XCR1+ DCs and NK cells or other IFN-γ–producing lymphocytes.
- Receptor editing and genetic variability in human autoreactive B cells
Lang et al. show in a humanized mouse model that human B cells undergo central tolerance via a combination of receptor editing and clonal deletion.
- A plasma cell differentiation quality control ablates B cell clones with biallelic Ig rearrangements and truncated Ig production
Srour et al. identify a quality control, truncated Ig exclusion checkpoint dampening terminal plasma cell differentiation by eliminating cells expressing nonfunctionally rearranged Igκ alleles