June 2014 | Volume 211, No. 6
Brief Definitive Reports
- Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
Fanca contributes to both somatic hypermutation and class switch recombination events in splenic B cells.
- Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry
Immune responses can be predicted by the chemical properties of systematically variable inorganic crystalline materials.
- Vagus nerve controls resolution and pro-resolving mediators of inflammation
Axonal guidance molecule netrin-1 promotes resolution of inflammation, with netrin-1 and resolvin D1 mutually inducing each other’s expression.
- A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice
Pharmacological disruption of the interaction between fibrinogen and β-amyloid reduces vascular amyloid deposition and improves cognition in a mouse model of Alzheimer’s disease.
- 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor
Endogenous 12-HHT, or a synthetic BLT2 agonist promotes epidermal wound closure by stimulating BLT2 on keratinocytes, inducing TNF and MMP production.
- Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency
A conserved regulatory element in intron 1 of UNC13D regulates Munc13-4 expression.
- Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
TNF signaling inactivation sensitizes AML cells to NF-kB inhibition but protects healthy hematopoietic stem progenitor cells from this treatment.
- Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells
The lymph node follicular dendritic cell (FDC) network is derived from the expansion and differentiation of marginal reticular cells, as are the new FDCs generated during an immune response.
- In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines
In vivo FRET demonstrates that ERK positively regulates the neutrophil recruitment cascade in the intestine by promoting adhesion and migration.
- A negative feedback loop mediated by the Bcl6–cullin 3 complex limits Tfh cell differentiation
Bcl6 and E3 ligase cullin 3 complexes mediate negative feedback regulation during thymocyte development and T cell activation to restrain exaggerated Tfh responses.
- Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance
LNSCs present peptide–MHCII complexes acquired from DCs to CD4+ T cells and induce T cell dysfunction by preventing their proliferation and survival.
- Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells
Neuropilin 1 regulates angiogenesis in a VEGF-independent manner via association with ABL1, suggesting that Imatinib represents a novel opportunity for anti-angiogenic therapy.
- CX3CL1 (fractalkine) and its receptor CX3CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin
Fractalkine interactions with its receptor, CX3CR1, regulate CD4+ T cell retention in atopic dermatitis and offer a potential therapeutic target in allergic disease.
- Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection
Bacteria can utilize a mammalian host siderophore to usurp host iron; however, the host can respond by down-regulating siderophore expression and up-regulating expression of an inhibitory siderophore-binding protein.
- Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus
Siglec-5 and Siglec-14 are shown to be paired inhibitory/activating receptors expressed on neutrophils and amniotic epithelium and modulating immune responses to group B Streptococcus.
- Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
In response to lung infection, pleural innate response activator B cells produce GM-CSF–dependent IgM and ensure a frontline defense against bacterial invasion.
- Counter-regulation of T cell effector function by differentially activated p38
Distinct mechanisms of p38 activation have opposing effects on T cell responses through differential regulation of NFATc1 activity.