May 2014 | Volume 211, No. 5
Brief Definitive Reports
- Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection
Type I IFN directly and selectively suppresses Cxcl2 expression by monocytes, and abrogates their ability to recruit neutrophils to the sensory ganglia following HSV-1 infection.
- Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
Granzyme B is expressed by hematopoietic stem cells (HSCs) and stromal cells in response to bacterial products or chemotherapy agents and limits HSC reconstitution potential.
- PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Hypoxia selectively up-regulates PD-L1 on myeloid-derived suppressor cells via HIF-1a, thus affecting T cell activation.
- Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system
CXCR7 antagonism augments oligodendrocyte progenitor cell proliferation to increase remyelination in vivo via CXCR4 activation.
- B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS
Intraneuronal activation of B-RAF kinase is sufficient to drive the growth of peripheral axon projections and enables robust regenerative axon growth in the injured optic nerve.
- Lymphatic function is required prenatally for lung inflation at birth
Neonatal mice lacking lymphatic vessels due to loss of lymphangiogenic factor CCBE1 or VEGFR3 function fail to inflate their lungs, suggestive of respiratory failure in infants with congenital pulmonary lymphangiectasia.
- The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
Zbtb20 facilitates terminal differentiation of B cells into antibody-secreting cells, and its expression is dependent on Irf4 and independent of Blimp1.
- Adjuvant-specific regulation of long-term antibody responses by ZBTB20
ZBTB20 promotes long-lived plasma cell survival after primary activation under alum but not TLR2- and TLR4-activating adjuvant conditions.
- IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies
Liver biopsies from patients with chronic hepatitis C reveal high IFN-λR1 expression, which can be induced with IFN-α and is associated with elevated ISG expression, the IFN-λ3 minor alleles, and nonresponsiveness to peg-IFN-α and ribavirin therapy.
- MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases
MyD88-dependent GM-CSF production by endothelial cells plays a role in the initiation of obesity-associated inflammation by promoting adipose macrophage recruitment and M1-like polarization.
- Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation
Strict, lineage-intrinsic requirement for continuous adult Gfi-1b expression at two distinct critical stages of erythropoiesis and megakaryopoiesis.
- Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function
LRRC8A recognizes a ligand expressed on thymic epithelial cells and its expression on thymocytes is required for their development and function.
- RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
Interaction between the inhibitory molecule PD-L2 on dendritic cells and repulsive guidance molecule b (RGMb) on lung macrophages is required to establish respiratory tolerance.
- Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection
Inhibition of T reg cells by type I IFNs is necessary for the generation of optimal antiviral T cell responses during acute LCMV infection.
- Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region
Unlike classical class-switch recombination, class switching to IgD occurs independently of the IgH 3′ regulatory region.
- Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties
Identification in humans of a bona fide marginal zone B cell population, which differentiates from a splenic marginal zone precursor through a NOTCH2 signaling pathway.