April 2014 | Volume 211, No. 4
Brief Definitive Reports
- RNA editing in RHOQ promotes invasion potential in colorectal cancer
Novel A-to-I RNA editing in the coding sequence of RHOQ leads to an amino acid substitution that promotes invasion in colorectal cancer.
- CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection
Interactions between cell adhesion molecules CRTAM and Cadm1 regulate the residency and maintenance of CD4+CD8+ and CD4+ T cells in the gut that can influence the immune response to infection.
- The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression
E4bp4 is required for commitment to the NK lineage and promotes NK development by directly regulating the expression of Eomes and Id2.
- IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs
The requirements for BALT formation are pathogen-dependent and, in the absence of FDC maturation, IL-17 can drive BALT formation via CXCL12 B cell recruitment.
- Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome
Salmonella lacking the TCA enzyme aconitase trigger NLRP3 inflammasome activation in infected macrophages, leading to elevated inflammatory responses and reduced virulence.
- BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups
BRAF-V600E expression is identified in hematopoietic progenitor and precursor myeloid dendritic cells in patients with high-risk LCH, and enforced expression of BRAF-V600E in CD11c+ cells recapitulates a high-risk LCH-like phenotype in mice.
- Dynamin 2–dependent endocytosis is required for sustained S1PR1 signaling
The endocytosis regulator dynamin 2 is required for the regulation of S1PR1 internalization and continued S1PR1 signaling in low S1P environments.
- Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential
Two interleukin-7 receptor mutants identified in human early T cell precursor leukemia are sufficient to induce disease in mice when expressed in primitive, Arf-null thymocytes.
- Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy
CTLA-4 blockade leads to enhanced activation of tumor-reactive T cells with concomitant up-regulation of ICOS, thus enabling their responses to be enhanced by ICOS engagement.
- EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization
EAT-2 promotes NK cell activation by linking SLAM family receptors to PLCγ, Ca++, and Erk signals to promote polarization and exocytosis of cytolytic granules towards target cells.