January 2014 | Volume 211, No. 1
Brief Definitive Report
- Initiation of MLL-rearranged AML is dependent on C/EBPα
C/EBPα collaborates with MLL-ENL to activate a group of genes that, together with Hoxa9 and Meis1, are responsible for the early events that transforms normal hematopoietic cells into leukemic cells
- Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
Estradiol enhances COX-2 expression and prostaglandin biosynthesis in TSC2-deficient cells via a rapamycin-insensitive, mTORC2-dependent mechanism.
- Jab1 regulates Schwann cell proliferation and axonal sorting through p27
Jab1 constitutes a regulatory molecule that integrates laminin211 signals in Schwann cells to govern cell cycle, cell number, and differentiation.
- Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
BLyS expression by GC follicular T cells is required for the efficient selection of high-affinity GC B cells.
- Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
- IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo
The signal 3 cytokines interleukin-12 and type I interferon sustain CD8 T cell division by prolonging expression of CD25 in vivo.
- CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
CD44loCD62Lhi regulatory T cells preferentially access IL-2 in T cell zones due to expression of CCR7
- TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
The induction of follicular regulatory T cells and control of germinal center reactions require the adaptor protein Traf3, in part because of Traf3-induced expression of ICOS.
- Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5–Dusp axis in the osteoclast
The transcription factor Stat5 inhibits the bone-resorbing function of osteoclasts, in part by inducing the expression of the phosphatases Dusp1 and Dusp2.
- Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia
Abnormal maternal inflammation leads to TNF-mediated fetal growth restriction and some features of preeclampsia that can be ameliorated with the nitric oxide mimetic nitroglycerin.