August 2013 | Volume 210, No. 9
- Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth
York and Bensinger discuss the ongoing cross talk between sterol metabolism and the immune system, highlighting the role of oxysterols in cancer progression.
Brief Definitive Reports
- Multicolor fate mapping of Langerhans cell homeostasis
The adult epidermal Langerhans cell network is formed by adjacent proliferative units composed of dividing cells and their terminally differentiated daughter cells.
- A role for gut-associated lymphoid tissue in shaping the human B cell repertoire
Transitional 2 B cells home to gut-associated lymphoid tissue and present an activated phenotype in healthy subjects, but gut immune compartments are depleted in SLE.
- Tristetraprolin regulation of interleukin 23 mRNA stability prevents a spontaneous inflammatory disease
Tristetraprolin deficiency results in enhanced IL-23 via dysregulated mRNA decay that leads to an inflammatory syndrome characterized by cachexia, myeloid hyperplasia, dermatitis, and erosive arthritis.
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
Antibodies that coengage activating FcγRs expressed by tumor-associated leukocytes facilitate the selective elimination of intratumoral T cells.
- Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor microenvironment.
- The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
Tumor-derived oxysterols recruit protumor neutrophils in an LXR-independent, CXCR2-dependent manner, thus favoring tumor growth by promoting neoangiogenesis and immunosuppression.
- Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood
Human OX40 is necessary for robust CD4+ T cell memory and confers selective protective immunity against HHV-8 infection in endothelial cells.
- Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis
The Wnt cargo receptor Evi maintains normal skin homeostasis and barrier function via Wnt secretion in the epidermis.
- Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome
Human L-ferritin deficiency causes reduced cellular iron availability and increased ROS production with enhanced oxidized proteins, which results in idiopathic generalized seizures and atypical restless leg syndrome.
- The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2
Deficiency of the microtubule-associated protein DCAMKL1 results in elevated bone mass via repression of osteoblast activation through Runx2 antagonization.
- Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC
The requirement for the TCR to interact with coagonists, endogenous MHC–peptide complexes which do not themselves activate the T cell, decreases as the strength of the CD8–class I interaction increases.
- IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells
Interleukin-25 preferentially elicits multipotent progenitor type 2 cells, which are distinct from other populations of type 2 innate lymphoid cells.
- Origin, trafficking, and intraepithelial fate of gut-tropic T cells
Tropism to the small intestinal epithelium is a general property of unconventional and conventional recent thymic emigrants, but for both cell types only GALT-related cycling thoracic duct lymphocytes are the precursors of cytotoxic intraepithelial lymphocytes.
- Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4
Lung dendritic cells promote lung homing by T cells in part via up-regulation of chemokine receptor CCR4.
- Lung dendritic cells induce migration of protective T cells to the gastrointestinal tract
Lung DCs induce the expression of gut-homing molecules on T cells, resulting in their migration to the GI tract and protection against Salmonella infection after immunization