July 2013 | Volume 210, No. 8
Brief Definitive Reports
- Immune history shapes specificity of pandemic H1N1 influenza antibody responses
The specificity of H1N1 antibody responses can be shifted to epitopes near the HA receptor–binding domain after sequential infections with viral strains that share homology in this region.
- The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
Somatic hypermutation in variable heavy chain rearranged regions is abrogated in the absence of the 3′ regulatory region enhancer, whereas transcription rate in the Ig heavy chain is only partially reduced.
- Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses
Blocking CCR8 inhibits entry of metastases from the collecting lymphatic vessel into the lymph node.
- BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
BRCA1 deficiency results in impaired Nrf2-mediated antioxidant responses followed by cell death, with estradiol rescuing the effect by inducing Nrf2 stabilization.
- The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia
miR-223 is upregulated by the transcription factor TAL1 in human T-ALL cells and suppress the FBXW7 tumor suppressor.
- Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection
Loss of GGPPS from childhood mumps infection or deletion in mice results in constitutively activated MAPK and NF-kB signaling that induces spermatogonium apoptosis, macrophage invasion into seminiferous tubules, and sterility.
- USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex
Ubiquitin-specific protease 18 inhibits ubiquitination of TAK1–TAB complexes to restrict IL-2 production and promote Th17 differentiation and autoimmune responses.
- CD4+ T helper cells use CD154–CD40 interactions to counteract T reg cell–mediated suppression of CD8+ T cell responses to influenza
CD40+ DCs interact with CD154+CD4+ T cells to abrogate T reg cell–mediated suppression of influenza-specific CD8+ T cells.
- CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response
The transcription factor DEC1 is induced by CD28 ligation and is required for optimal CD4+ T cell responses and the development of EAE.
- MK5 activates Rag transcription via Foxo1 in developing B cells
The kinase MK5 phosphorylates and activates Foxo1 at serine 215, and this modification is required for Foxo1 to induce Rag transcription.
- Apoptosis and dysfunction of blood dendritic cells in patients with falciparum and vivax malaria
Acute Plasmodium infections in humans result in dendritic cell dysfunction and apoptosis caused in part by elevated levels of IL-10.