July 2013 | Volume 210, No. 7
Brief Definitive Report
- Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity
Loss of antiproliferative gene TOB1 results in more severe EAE driven by augmented pathogenic T cell responses.
- Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia
Notch1 signaling sustains the proinflammatory behavior of Th1 cells, implicated in the development of aplastic anemia in humans and mice.
- AP4 is a mediator of epithelial–mesenchymal transition and metastasis in colorectal cancer
The transcription factor AP4 is a critical regulator of epithelial–mesenchymal transition, migration, invasion, and metastasis in colorectal cancer cells.
- PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion
A subset of human Nestin+ mesenchymal stem cells expresses PDGFRα and CD51, and these markers can be used for prospective isolation of these cells.
- The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter
HPV16-positive cervical cancer lesions contain NFκB–ERα nuclear complexes to repress the TLR9 promoter.
- Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
Indoleamine 2,3-dioxygenase suppresses infiltration and accumulation of tumor-reactive T cells in the context of anti–CTLA-4 immunotherapy and attenuates the anti-tumor efficacy.
- Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease
Identification of peptides that form complexes with beryllium and class II HLA molecules and are recognized by CD4+ T cells from patients with chronic beryllium disease.
- Shp1 regulates T cell homeostasis by limiting IL-4 signals
Absence of the phosphatase Shp1 in T cells does not affect the TCR signaling threshold but results in IL-4 sensitivity and memory phenotype cells.
- Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling
MDSC-derived nitric oxide supports the development of Th17 cells in ovarian cancer dependent on the induction of endogenous NOS2 and the cGMP–cGK pathway in Th17 cells.
- N-ras couples antigen receptor signaling to Eomesodermin and to functional CD8+ T cell memory but not to effector differentiation
N-ras−/− CD8+ T cells have an intrinsic defect in Eomes expression resulting in impaired generation of protective memory cells that can be rescued by enforced Eomes expression.
- Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID
Ongoing transcription of the Ig gene coupled with temporary pausing within the targeted region facilitates somatic hypermutation.