June 2013 | Volume 210, No. 6
Brief Definitive Reports
- MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
Ubiquitination of MHCII molecules on dendritic cells is essential for the development of natural regulatory T cells
- TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells
Loss of TRAF3 results in reduced TCR signaling and defective up-regulation of T-bet and CD122 in iNKT cells that impairs their proliferation and survival.
- Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
RB family genes control T cell production and promote thymic involution through reducing Foxn1 expression in thymic epithelial cells.
- IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction
A new polymorphism near the IL28B locus negatively affects induction of IL28B and exhibits strong predictive value for HCV treatment response and spontaneous resolution.
- Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation
Retinoic acid attenuates colitis and is associated with increased IL-22 production from γδ T cells and innate lymphoid cells and enhanced antimicrobial peptide expression.
- Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia
Transfer of FAP-reactive T cells into mice bearing a variety of subcutaneous tumors mediated limited antitumor effects and induced significant cachexia and lethal bone toxicities
- Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia
Ablation of stromal cells expressing fibroblast activation protein-α (FAP) results in cachexia and anemia, and loss of these cells is seen in transplantable tumor models.
- IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
IL-2–dependent adaptive-innate lymphocyte cross talk tunes NK cell reactivity and is limited by T reg cells.
- Differentiation of CD8 memory T cells depends on Foxo1
The transcription factor Foxo1 is required for the differentiation of memory CD8+ T cells, and its absence hinders clearance of secondary infections.
- Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins
Dexamethasone suppresses ER stress in inflammatory bowel disease by promoting correct protein folding and ER-associated degradation.
- Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators
PLA2G2D ameliorates skin inflammation through mobilizing pro-resolving lipid mediators.
- Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
Mutating anti–HIV-1 broadly neutralizing antibodies increases their breadth and reduces pathways for viral escape through mutation.
- CD47 fusion protein targets CD172a+ cells in Crohn’s disease and dampens the production of IL-1β and TNF
CD172a+ cells producing IL-1β and TNF are increased in inflamed tissues in Crohn’s disease and can be targeted by CD47 fusion protein.