April 2013 | Volume 210, No. 4
Brief Definitive Reports
- Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies
Synthetic retinoids activate RARA- or PML/RARA-dependent transcription, but fail to degrade RARA or PML/RARA protein, which is insufficient for eradication of acute promyelocytic leukemia.
- Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
Eliminating key glycosylation sites on HIV envelope (Env) restores binding of the germline versions of known broadly neutralizing anti-Env antibodies.
- RhoGEF12 controls cardiac remodeling by integrating G protein– and integrin-dependent signaling cascades
RhoGEF12 is required for stretch-induced RhoA activation, and its absence protects mice against overload-induced heart failure.
- The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
The thymic medulla and an intact mTEC compartment are needed for the development of nTreg cells and negative selection of conventional T cells but not their further maturation.
- Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength
Jagged2 preferentially signals through Notch3 to promote γδ T cell development.
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis
A novel pre-TCRα (pTα) reporter mouse reveals that expression of pTα is confined to the T lineage and does not occur on prethymic progenitors.
- Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27–CD70 pathway
CD27–CD70 signals are required for optimal development of natural regulatory T cells from the thymus.
- Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin
Anti–4-1BB treatment of tumor-bearing or intracellular pathogen infected mice generates a population of Eomes+KLRG1+ tumor infiltrating T cells that have enhanced cytotoxic activity.
- PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
PD-L1 decreases anti-viral CD8+ T cell motility and PD-1 blockade restores motility in the presence of high viral loads.
- Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance
Lung-resident antigen-presenting macrophages promote tolerance to inhaled antigens via the induction of regulatory T cells.
- O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia
Removal of 9-O-acetyl residues from the cell surface N-acetylneuraminic acid makes ALL cells drug sensitive.
- Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice
Reduction of the CHOP target Gadd34 restores motor function in P0S63del mice with demyelinating neuropathy.
- Plasma glutamate–modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury–induced acute lung injury
Activation of adenosine A2A receptor aggravates lung damage in a neurogenic mouse model of acute lung injury (ALI) but protects against nonneurogenic ALI.