March 2013 | Volume 210, No. 3
Brief Definitive Reports
- Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome
A primary immunodeficiency syndrome caused by loss-of-function mutations in the IL-21 receptor exhibits impaired B, T, and NK cell function.
- Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
Synovial IgG-expressing B cells from patients with rheumatoid arthritis show specificity for citrullinated autoantigens.
- Germinal center B cells govern their own fate via antibody feedback
High-affinity antibodies reenter germinal centers (GCs) and limit antigen access, thus causing sustained directional evolution in GCs toward higher-affinity antibody production.
- Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation
Endothelial cell ablation of the lymphotoxin-β receptor results in failure to develop peripheral lymph nodes and normal high endothelial venues, which impairs lymphocyte homing.
- BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid
Induction of gut-homing receptors in T cells in response to retinoic acid requires the transcription factor BATF.
- IL-1R1 is required for dendritic cell–mediated T cell reactivation within the CNS during West Nile virus encephalitis
IL-1R1 signaling drives T cell activation in the CNS via effects on DC activation.
- IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation
IL-27 promotes the differentiation of monocytes to HIV-resistant macrophages by down-regulating host factor SPTBN1.
- Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
Innate lymphoid type 2 cells maintain eosinophils and alternatively activated macrophages in visceral fat via the production of IL-5 and IL-13.
- Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia
STAT3-mediated induction of Reg3γ enhances bacteriostatic and bactericidal activity to pulmonary Staphylococcus aureus.
- Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination
Genetic deficiency for endoglin leads to increased metastatic capability by weakening the endothelial cell barrier.
- Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ
Cytotoxic T cells increase leukemia stem cell numbers in a murine model of chronic myeloid leukemia.
- TGFβ restores hematopoietic homeostasis after myelosuppressive chemotherapy
Blocking TGFβ signaling after chemotherapy accelerates hematopoietic reconstitution and delays the return of cycling HSCs to quiescence.