December 2013 | Volume 210, No. 13
- Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia
Pandolfi et al. provide an in-depth discussion on the synergism between all-trans-retinoic acid and arsenic trioxide treatment and their mechanisms of action on acute promyelocytic leukemia.
Brief Definitive Reports
- Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals
Ikaros is essential for pre-BCR down-regulation, Igκ germline transcription, Ig light chain recombination, and pre-B cell differentiation, in part by antagonizing IL-7–dependent gene regulation.
- Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo
Cis-element requirement for the emergence of HSCs in the AGM and for hemogenic endothelium to generate HSC-containing c-Kit+ cell clusters.
- Gata2 is required for HSC generation and survival
GATA2 function is essential for the generation of HSCs during the stage of endothelial-to-hematopoietic cell transition and thereafter for HSC survival
- Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
Chemotherapy stimulates cancer-associated fibroblasts to secrete interleukin-17A to provide maintenance cues to support the growth of colorectal cancer-initiating cells.
- KIT oncogene inhibition drives intratumoral macrophage M2 polarization
Imatinib reduces tumor cell KIT signaling and causes tumor cell apoptosis, which drives TAMs to shift from M1- to M2-like in mouse and human GIST.
- IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity
The transcription factor IRF4 limits the retention of B cells in the marginal zone by inhibiting NOTCH2 signaling.
- RNA recognition by human TLR8 can lead to autoimmune inflammation
High expression level of human TLR8 in mice results in spontaneous, multiorgan inflammation attributable in part to increased DC activation.
- MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
Antigen presentation, but not antibody secretion, by B cells drives CNS autoimmunity induced by immunization with human MOG.
- A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis
Type 2 innate lymphoid cells promote skin inflammation in mice and men, in part by producing IL-5 and IL-13 in response to IL-33
- IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
IL-9 acts as an autocrine amplifier of type 2 innate lymphoid cell function to promote tissue repair in the recovery phase of helminth-induced lung infection.
- Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks
Langerhans cell homeostasis and differentiation depends on PU.1, the latter via regulation of TGF-β–dependent binding of PU.1 to the regulatory elements of RUNX3.
- Nfil3-independent lineage maintenance and antiviral response of natural killer cells
Inflammatory cytokines drive NK cell expansion in the absence of the transcription factor Nfil3, and Nfil3 is dispensable for the maintenance and function of mature NK cells.