It has been shown in this investigation that digitalis, administered orally to patients, can modify the T wave in the electrocardiogram. When the T wave in the initial curve is directed upward, the first change noticed is a lowering, and the final change is an inversion of the wave. It is not only the wave itself, but that portion of the curve between the end of R and the end of T which is involved. Instances in which the initial T waves have other than upright forms are described and their behavior under the influence of digitalis has been indicated. This influence of digitalis on the T wave may be detected in thirty-six to forty-eight hours after the administration of digitalis has commenced; it may persist as long as twenty-two days after the administration has been stopped. Instances where it persisted only five days have been encountered. The unexpected length of duration of the sign probably explains why a second treatment with digitalis requires a smaller amount of the drug to produce the same effect, than the first.
Article|
June 01 1915
THE INFLUENCE OF DIGITALIS ON THE T WAVE OF THE HUMAN ELECTROCARDIOGRAM
Alfred E. Cohn,
Alfred E. Cohn
From the Hospital of The Rockefeller Institute for Medical Research.
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Francis R. Fraser,
Francis R. Fraser
From the Hospital of The Rockefeller Institute for Medical Research.
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Ross A. Jamieson
Ross A. Jamieson
From the Hospital of The Rockefeller Institute for Medical Research.
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Alfred E. Cohn
From the Hospital of The Rockefeller Institute for Medical Research.
Francis R. Fraser
From the Hospital of The Rockefeller Institute for Medical Research.
Ross A. Jamieson
From the Hospital of The Rockefeller Institute for Medical Research.
Received:
April 07 1915
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1915, by The Rockefeller Institute for Medical Research New York
1915
J Exp Med (1915) 21 (6): 593–603.
Article history
Received:
April 07 1915
Citation
Alfred E. Cohn, Francis R. Fraser, Ross A. Jamieson; THE INFLUENCE OF DIGITALIS ON THE T WAVE OF THE HUMAN ELECTROCARDIOGRAM . J Exp Med 1 June 1915; 21 (6): 593–603. doi: https://doi.org/10.1084/jem.21.6.593
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