November 2012 | Volume 209, No. 12
Brief Definitive Reports
- Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
Anti-ApoE antibody reduces amyloid deposition and enhances the microglial response to Aβ plaques in an Alzheimer’s disease mouse model.
- Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
Deletion of early growth response gene Egr2 prevents anergy induction through diacylglycerol kinase α and restores Ras/MAPK signaling in T cells.
- Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression
Distinct nuclear subsets of cyclin D3 differ in their subcompartmentalization, function, and regulation.
- Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress
Endogenous thymidine plays a critical role in the induction of replication stress in thymocytes.
- Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung
Deletion of p38 MAP kinase p38 d results in decreased alveolar neutrophil accumulation and attenuation of acute lung injury through activation of protein kinase D1 and PTEN.
- Congenital B cell lymphocytosis explained by novel germline CARD11 mutations
Germline mutations in CARD11 that result in constitutive NF-κB activation and selective B cell expansion underlie congenital B cell lymphocytosis.
- Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus
Two cytokines that signal through the common gamma chain receptor, IL-7 and IL-15, are responsible for the differentiation of developing thymocytes into CD8+ cytotoxic lineage T cells in mice.
- Procontractile G protein–mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling
The G proteins Gα12/Gα13 and Gαq/Gα11 have opposing effects on vascular remodeling by differentially regulating vascular smooth muscle cell differentiation.
- ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
proNGF and p75NTR are induced following fatal myocardial infraction and are required for the development of microvascular injury.
- Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity
Expressing a wild mouse Fcgr2b promoter variant in C57BL/6 mice enhances germinal center responses and increases affinity maturation and autoantibody production.