May 2011 | Volume 208, No. 5
Brief Definitive Reports
- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
By transactivating expression of miRNAs that repress expression of the ZEB1 and ZEB2 transcription factors, p53 inhibits the epithelial–mesenchymal transition.
- Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
IL7R-activating mutations identified in B-ALL and T-ALL patient leukemic cells facilitate cytokine-independent growth.
- Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion
Trypanosoma cruzi takes advantage of a sphingomyelinase-dependent plasma membrane repair pathway to gain access to host cells.
- Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
HSCs lacking the guanosine nucleotide-binding protein Gimap5, which stabilizes expression of the Mcl-1 Bcl2 family protein, exhibit impaired survival and long-term repopulation capacity.
- Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain
Inducible alterations in expression of cyclinD1 and cdk4 in the adult mouse hippocampus allow temporal control and manipulation of neurogenesis.
- Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero
Newly identified tissue-resident vascular precursor cells are recruited into growing vessels and contribute to vasculogenesis in adult mice.
- Platelet-derived serotonin links vascular disease and tissue fibrosis
Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
- A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
A monoclonal anti-CD160 antibody inhibits the growth of new vessels in pathological ocular and tumor neoangiogenesis but not in healthy tissues.
- The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
T-bet acts as a functional repressor in association with Bcl-6 to antagonize SOCS1, SOCS3, TCF-1, and late-stage IFN-γ to regulate Th1 development.
- Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses
Homing of conventional T cells to NALT is primarily dependent on L-selectin–PNAd interactions, whereas homing of regulatory T cells also depends on PSGL1- and CD44-mediated adhesion.
- Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology
Interleukin-10 acts directly on CD45RBlo but not CD45RBhi cells to control colitis upon transfer into Rag1-deficient recipients.
- MHCII glycosylation modulates Bacteroides fragilis carbohydrate antigen presentation
N-linked glycans on class II MHC molecules are required for the presentation of glycoantigens, but not peptide antigens.
- Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity
By dynamically remodeling the cortical actin network, ezrin and moesin control BCR microcluster formation, organization, and integrity.
- Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation
Host macrophages protect against graft-versus-host disease in part by engulfing donor T cells and inhibiting their proliferation.
- Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes
By engaging CD36 on murine macrophages, thrombospondin-1 prevents excessive macrophage VEGF-C production and corneal neovascularization.
- KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice by regulating IL-4–generating invariant natural killer T cells
Transcription factor KLF13 regulates the elevated numbers of iNKT cells in the BALB/c versus C57BL/6 thymus that results in production of sufficient levels of IL-4 to generate memory-like CD8+ T cells.
- Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
MCMV-infected cells are recognized by multiple MHC class I–restricted Ly49-activating receptors in genetically distinct mouse strains.