November 2010 | Volume 207, No. 12
Brief Definitive Reports
- A requirement for Lim domain binding protein 1 in erythropoiesis
Lim domain-binding protein 1, a core subunit of complexes containing Scl, Gata1, and Lmo2, is needed continuously throughout erythropoiesis and megakaryopoiesis in adult mice.
- Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression
One-time treatment with an antibody against BTLA provides long-term protection against graft-versus-host disease without affecting effector T cell responses to tumors or pathogens.
- Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2–P2X7 pathway
Extracellular NAD+ affects the survival and function of regulatory T cells, and NAD-mediated depletion of regulatory T cells promotes anti-tumor responses in mice.
- A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling
A BAFF receptor mutation associated with non-Hodgkin lymphoma provides new insight into the proximal players of normal BAFF-R signaling.
- Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation
The reticulon protein Nogo-B is highly expressed in the lungs, and its loss augments lung inflammation in part as a result of decreased expression of the antiinflammatory protein PLUNC.
- Lack of the purinergic receptor P2X7 results in resistance to contact hypersensitivity
Engagement of P2X7 on mouse dendritic cells, presumably by ATP released in response to contact allergen, is needed for IL-1β production and the sensitization phase of contact hypersensitivity.
- IκBβ is an essential co-activator for LPS-induced IL-1β transcription in vivo
IkBβ forms a complex with the NF-κB subunits RelA and c-Rel that inhibits the transcription of IL-1β and other genes. Mice lacking IkBβ are protected against LPS-induced shock.
- Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival
Cytosolic proliferating cell nuclear antigen (PCNA) binds to procaspases and protects human neutrophils from apoptosis.
- Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling
By binding to the interleukin 17 receptor (IL-17R), TRAF3 blocks formation of the IL-17R–Act1–TRAF6 complex and inhibits downstream signaling.
- Cytomegalovirus immunoevasin reveals the physiological role of “missing self” recognition in natural killer cell dependent virus control in vivo
Natural killer cell recognition of “missing self” contributes meaningfully to control of mouse cytomegalovirus infection in vivo.
- Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation
The novel polyI:C-inducible membrane protein INAM triggers dendritic cell–mediated natural killer cell activation.
- Mouse CD8α+ DCs and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
In humans and mice, CD8α+ conventional dendritic cells are the primary source of interferon-λ released in response to the adjuvant and Toll-like receptor 3 agonist poly IC.
- Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse
IL-12 is enriched at the immunological synapse in TLR-activated dendritic cells interacting with antigen-specific CD8+ T cells; synaptic delivery of IL-12 induces IFN-γ production in the T cell.
- Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics
Real-time imaging defines the dynamics of TCR and T cell motility during early T cell activation in lymph nodes.
- Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice
The leukemogenic effects of Myc drive recurrent trisomy in a mouse model of acute myeloid leukemia.