Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generating mice genetically deficient in IL-7R. Mutant mice display a profound reduction in thymic and peripheral lymphoid cellularity. Analyses of lymphoid progenitor populations in IL-7R-deficient mice define precisely those developmental stages affected by the mutation and reveal a critical role for IL-7R during early lymphoid development. Significantly, these studies indicate that the phase of thymocyte expansion occurring before the onset of T cell receptor gene rearrangement is critically dependent upon, and mediated by the high affinity receptor for IL-7.
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November 01 1994
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.
J J Peschon,
J J Peschon
Immunex Research and Development Corporation, Seattle, Washington 98101.
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P J Morrissey,
P J Morrissey
Immunex Research and Development Corporation, Seattle, Washington 98101.
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K H Grabstein,
K H Grabstein
Immunex Research and Development Corporation, Seattle, Washington 98101.
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F J Ramsdell,
F J Ramsdell
Immunex Research and Development Corporation, Seattle, Washington 98101.
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E Maraskovsky,
E Maraskovsky
Immunex Research and Development Corporation, Seattle, Washington 98101.
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B C Gliniak,
B C Gliniak
Immunex Research and Development Corporation, Seattle, Washington 98101.
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L S Park,
L S Park
Immunex Research and Development Corporation, Seattle, Washington 98101.
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S F Ziegler,
S F Ziegler
Immunex Research and Development Corporation, Seattle, Washington 98101.
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D E Williams,
D E Williams
Immunex Research and Development Corporation, Seattle, Washington 98101.
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C B Ware,
C B Ware
Immunex Research and Development Corporation, Seattle, Washington 98101.
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J D Meyer,
J D Meyer
Immunex Research and Development Corporation, Seattle, Washington 98101.
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B L Davison
B L Davison
Immunex Research and Development Corporation, Seattle, Washington 98101.
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J J Peschon
Immunex Research and Development Corporation, Seattle, Washington 98101.
P J Morrissey
Immunex Research and Development Corporation, Seattle, Washington 98101.
K H Grabstein
Immunex Research and Development Corporation, Seattle, Washington 98101.
F J Ramsdell
Immunex Research and Development Corporation, Seattle, Washington 98101.
E Maraskovsky
Immunex Research and Development Corporation, Seattle, Washington 98101.
B C Gliniak
Immunex Research and Development Corporation, Seattle, Washington 98101.
L S Park
Immunex Research and Development Corporation, Seattle, Washington 98101.
S F Ziegler
Immunex Research and Development Corporation, Seattle, Washington 98101.
D E Williams
Immunex Research and Development Corporation, Seattle, Washington 98101.
C B Ware
Immunex Research and Development Corporation, Seattle, Washington 98101.
J D Meyer
Immunex Research and Development Corporation, Seattle, Washington 98101.
B L Davison
Immunex Research and Development Corporation, Seattle, Washington 98101.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1994) 180 (5): 1955–1960.
Citation
J J Peschon, P J Morrissey, K H Grabstein, F J Ramsdell, E Maraskovsky, B C Gliniak, L S Park, S F Ziegler, D E Williams, C B Ware, J D Meyer, B L Davison; Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.. J Exp Med 1 November 1994; 180 (5): 1955–1960. doi: https://doi.org/10.1084/jem.180.5.1955
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