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jem Home » 1993 Archive » 1 February » 177 (2): 257
Article

Thymic origin of embryonic intestinal gamma/delta T cells.

D Dunon, M D Cooper, B A Imhof
D Dunon
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M D Cooper
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B A Imhof
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DOI: 10.1084/jem.177.2.257 | Published February 1, 1993
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Abstract

Current evidence suggests both thymic and extrathymic origins for T cells. Studies in mice favor an in situ origin for a prominent population of intestinal intraepithelial lymphocytes that express gamma/delta T cell receptor (TCR). This developmental issue is explored in an avian model in which the gamma/delta lymphocytes constitute a major T cell subpopulation that is accessible for study during the earliest stages of lymphocyte development. In the chick embryo, cells bearing the gamma/delta TCR appear first in the thymus where they reach peak levels on days 14-15 of embryogenesis, just 2 d before gamma/delta T cells appear in the intestine. Using two congenic chick strains, one of which expresses the ov antigen, we studied the origin and kinetics of intestinal colonization by gamma/delta T cells. The embryonic gamma/delta+ thymocytes homed to the intestine where they survived for months, whereas an embryonic gamma/delta- thymocyte population enriched in thymocyte precursors failed to give rise to intestinal gamma/delta+ T cells. Embryonic hemopoietic tissues, bone marrow, and spleen, were also ineffective sources for intestinal gamma/delta+ T cells. Intestinal colonization by gamma/delta+ thymocytes occurred in two discrete waves in embryos and newly hatched birds. The data indicate that intestinal gamma/delta T cells in the chicken are primarily thymic migrants that are relatively long-lived.

© 1993 Rockefeller University Press
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Thymic origin of embryonic intestinal gamma/delta T cells.
D Dunon, M D Cooper, B A Imhof
Journal of Experimental Medicine Feb 1993, 177 (2) 257-263; DOI: 10.1084/jem.177.2.257

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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