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jem Home » 1992 Archive » 1 September » 176 (3): 667
Article

Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone.

M H Wauben, C J Boog, R van der Zee, I Joosten, A Schlief, W van Eden
M H Wauben
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C J Boog
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R van der Zee
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I Joosten
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A Schlief
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W van Eden
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DOI: 10.1084/jem.176.3.667 | Published September 1, 1992
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Abstract

Peptide analogues of disease-associated epitopes were studied for inhibition of experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA) in Lewis rats. EAE- and AA-associated analogues were selected as competitors because of their in vitro inhibitory activity on proliferation of encephalitogenic and arthritogenic T cells. Although the EAE-associated competitor had a superior major histocompatibility complex (MHC) binding affinity, the AA-associated competitor was a better inhibitor of the in vitro proliferation of arthritogenic T cells. Furthermore, although in vivo EAE was inhibited by both competitors, AA was only inhibited by the AA-associated competitor. Remarkably, in contrast to what was expected of a regular MHC competitor peptide, the AA-associated peptide analogue also prevented AA upon immunization before disease induction and appeared to induce T cell responses that crossreacted with the original disease-associated epitope. Therefore, it is concluded that antigen-specific regulatory mechanisms were involved in synergy with MHC competition. The integration of both qualities into a single "competitor-modulator" analogue peptide may lead to the development of novel, more effective, disease-specific immunomodulatory peptides.

© 1992 Rockefeller University Press
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Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone.
M H Wauben, C J Boog, R van der Zee, I Joosten, A Schlief, W van Eden
Journal of Experimental Medicine Sep 1992, 176 (3) 667-677; DOI: 10.1084/jem.176.3.667

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The Journal of Experimental Medicine: 215 (4)

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April 2, 2018
Volume 215, No. 4

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