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jem Home » 1990 Archive » 1 November » 172 (5): 1513
Article

Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.

W Mourad, R S Geha, T Chatila
W Mourad
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R S Geha
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T Chatila
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DOI: 10.1084/jem.172.5.1513 | Published November 1, 1990
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Abstract

Antigenic stimulation is associated with enhanced adhesion between T cells and antigen-presenting cells (APC). Binding of ligands to the T cell antigen receptor activates the adhesion function of lymphocyte function-associated molecule 1 (LFA-1; CD11a/CD18). We demonstrate here that ligand binding to major histocompatibility complex class II (Ia) molecules also activates LFA-1 function, providing a reciprocal mechanism for the induction of adhesion between T cells and Ia+ APC. Adhesion was affected by a qualitative change in LFA-1 molecules and was reversed by the protein kinase C inhibitor sphingosine. These results define a novel role for Ia molecules as signal transducing receptors that regulate LFA-1-dependent adhesion via a putative, Ia-coupled protein kinase(s).

© 1990 Rockefeller University Press
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Engagement of major histocompatibility complex class II molecules induces sustained, lymphocyte function-associated molecule 1-dependent cell adhesion.
W Mourad, R S Geha, T Chatila
Journal of Experimental Medicine Nov 1990, 172 (5) 1513-1516; DOI: 10.1084/jem.172.5.1513

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The Journal of Experimental Medicine: 215 (4)

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